Glucovance (gylburide + metformin) is a prescription drug and is used as an adjunct t o diet and exercise, and as initial therapy, to improve glycemic control in type two diabetes also know as diabetes mellitus. Glucovance (gylburide + metformin) is a combination of two oral hypoglycemic agents (gylburide and metformin) to help control blood sugar in those who cannot be controlled satisfactorily with diet and exercise alone. Glucovance (gylburide + metformin) can also be used as a second line therapy when diet, exercise, and initial therapy with a sulfonylurea or metformin do not provide adequate control in those with type two diabetes.  If additional control is needed other medications may be added to Glucovance (gylburide + metformin).    

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Glucovance (gylburide + metformin) stimulates release of insulin from the pancreas, which is dependent upon functioning pancreatic beta islets. Extra pancreatic effects may also be involved in the long term effectiveness of Glucovance (gylburide + metformin). Glucovance (gylburide + metformin) decreased hepatic glucose production, decreases intestinal absorption f glucose and improves insulin sensitivity by increasing peripheral glucose uptake utilization. So the mechanisms are complementary.

For type two diabetes not previously treated, the initial dose of Glucovance (gylburide + metformin) is 1.25 mg/250 mg once a day with a meal.  Do not use Glucovance (gylburide + metformin) 5 mg/500mg as initial therapy die to the increased risk of hypoglycemia. Make dosage increased on increments of 1.25mg/250mg per day every two weeks up to the minimum effective dose needed to control blood glucose, not to exceed 20mg gylburide/2,000 mg metformin daily. Type two diabetes in previously treated clients the initial dose of 2.5mg/500 mg or 5 mg/500 mg twice a day with the morning and evening meal.

Some side effects have been reported with the use of Glucovance (gylburide + metformin which include urinary tract infection, diarrhea, hypoglycemia, headache, abdominal pain and dizziness.

Always consult your physician for any questions you may have on this drug if there is information listed that you do not understand. Drink plenty of water when taking your medication and unless it states to do so never take your medicine on an empty stomach. It is helpful to establish a time each day to take this medicine to maintain consistency. Please follow the directions closely when taking this medicine as there are side effects.  Never allow anyone else to take this medicine without a prescription. If you have not taken all this medicine prescribed do not dispose of it down the toilet call your local poison Control office for direction for proper disposal.